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KMID : 0043319940170020066
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.66 ~ p.70
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Oxazole, Pyrazole and Piperidine Derivatives Having an o-Hydroxy-aryl Moirty with Anticipated Molluscicidal Activity
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Nawwar Galal-A.M.
Swellem Randa-H.
Ibrahim Amal-M
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Abstract
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The condensation reactions of hippuric acid and tis furyl derivative with salicyladehydes or that of salicylhippuric acid analogues with furadehyde led to the comesponding oxazoles. These wre subsequently treated with hydrazine hydrate, hydroxylamine or subjected to alkaline hydrolysis to yield new o-hydroxyaryl or salicyl containing derivatives. 5-Substituted salicylanilides were treated with piperidine and formaldehyde in a Mannich type reaction affording the corresponding 3-(N-piperidinomethyl) salicylanilides. It was noticed that the presence of an electron donating group in in position 3 in the salicylanilide moiety decrease the mollusicidal activity.
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KEYWORD
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Salicylanilides, Oxazoles, Pyrazoles, Mannich reaction, Molluscicidal activity
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